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Kategoria: OncoReview
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OncoReview 2016; 4(24): 169-174

Autorzy: Jan Styczyński

Streszczenie: 

Abstract: This paper reports on diagnostic and therapeutic management of pulmonary invasive fungal disease (IFD) in a child with relapsed acute myeloid leukaemia, undergoing chemotherapy followed by haematopoietic stem cell transplantation. Surgical management with resection of the involved lung tissue was based on the location of fungal infiltrates close to large circulatory vessels. After examination of resected pulmonary tissue, a diagnosis of proven IFD was done. This case report is an example that aspergillosis is usually the cause for pulmonary IFD. Pharmacotherapy of pulmonary IFD should be based on compounds with good penetration to lung tissue: amphotericin B lipid form or voriconazole.

Słowa kluczowe:

Key words: invasive fungal disease, invasive fungal infection, pulmonary aspergillosis, chemotherapy, haematopoietic stem cell transplantation, amphotericin B lipid form
Informacje o publikacji
Dodany 2017-09-05
DOI:
Wielkość 564.62 KB
Dodany przez Marcin Kuźma
Pobrany 179


OncoReview 2016; 4(24): 162-168

Autorzy: Przemysław Witek, Marta Gutowska

Streszczenie: 

Abstract: Acromegaly is a rare disease, caused by growth hormone (GH) hypersecretion and secondarily elevated insulin-like growth factor1 (IGF-1) level. Nearly all patients with acromegaly suffer from somatotroph pituitary adenoma. The main goal of treatment is to normalise both GH and IGF-1 levels, which reduces symptoms, complications and mortality. Transsphenoidal selective adenomectomy performed by an experienced neurosurgeon is the first-line therapy. Therapy with somatostatin analogues (SSA) is used as a neoadjuvant treatment prior to surgery and in a persistent disease following the surgery.The long-acting somatostatin analogues reduce serum GH/IGF-1 levels and tumour volume. In this clinical review, mechanisms and role of 1st and 2nd generation somatostatin analogues in the treatment of patients with acromegaly are presented, with particular emphasis on the effects on somatotroph pituitary adenoma volume reduction.

Słowa kluczowe:

Key words: pasireotide, lanreotide, octreotide, long-acting somatostatin analogues, tumour volume reduction, insulin-like growth factor 1, growth hormone, acromegaly, somatotroph pituitary adenoma
Informacje o publikacji
Dodany 2017-09-05
DOI:
Wielkość 285.39 KB
Dodany przez Marcin Kuźma
Pobrany 168


OncoReview 2016; 3(23): 103-112

Autorzy: Lucia Setteyova, Ljuba Bacharova, Beata Mladosievicova

Streszczenie: 

Abstract: A growing number of targeted anticancer agents has shown the unexpected ability to induce QT interval prolongation. In addition, standard chemotherapeutics and a variety of conditions such as electrolyte abnormalities, endocrine disorders, cardiac diseases, nutritional disturbances and other factors may be associated with long QT syndrome in cancer patients. Prolongation of the QT interval can lead to life-threatening ventricular arrhythmias, including ‘torsade de pointes’ (TdP). The association between long QT interval and ventricular arrhythmias remains the subject of many controversies. The QT interval represents the time interval of both ventricular depolarization and repolarization. Not only abnormalities of ion channels, but also changes in the myocardial microarchitecture and other factors and disorders frequently seen in cancer patients may participate in its prolongation and potential risk of ventricular arrhythmias. The aim of this review was to summarize current knowledge about QT prolongation in cancer patients with the special focus on targeted therapy.

Słowa kluczowe:

Key words: QT prolongation, targeted therapy, torsade de pointes, cancer patients
Informacje o publikacji
Dodany 2017-09-05
DOI:
Wielkość 199.11 KB
Dodany przez Marcin Kuźma
Pobrany 181


OncoReview 2016; 3(23): 100-102

Autorzy: Saro Armenian, Daniel Lenihan

Streszczenie: 

Abstract: The initial presentation in this session was a comprehensive outline of Late onset cardiotoxicity: incidence, risk and individual risk prediction by Dr Gregory Armstrong from St. Jude’s Children’s Hospital in Memphis, TN.

Słowa kluczowe:

Key words: 
Informacje o publikacji
Dodany 2017-09-05
DOI:
Wielkość 174.54 KB
Dodany przez Marcin Kuźma
Pobrany 162


OncoReview 2016; 3(23): 97-99

Autorzy: Daniel Lenihan, Benjamin D. Humphreys

Streszczenie: 

Abstract: An outstanding opening lecture by Thomas Wang, MD, Chief of the Division of Cardiovascular Medicine at Vanderbilt UniversityMedical Center, outlined the field of biomarkers in cardio-oncology.

Słowa kluczowe:

Key words: 
Informacje o publikacji
Dodany 2017-09-05
DOI:
Wielkość 110 KB
Dodany przez Marcin Kuźma
Pobrany 161