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Kategoria: OncoReview
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OncoReview 2016; 3(23): 103-112

Autorzy: Lucia Setteyova, Ljuba Bacharova, Beata Mladosievicova

Streszczenie: 

Abstract: A growing number of targeted anticancer agents has shown the unexpected ability to induce QT interval prolongation. In addition, standard chemotherapeutics and a variety of conditions such as electrolyte abnormalities, endocrine disorders, cardiac diseases, nutritional disturbances and other factors may be associated with long QT syndrome in cancer patients. Prolongation of the QT interval can lead to life-threatening ventricular arrhythmias, including ‘torsade de pointes’ (TdP). The association between long QT interval and ventricular arrhythmias remains the subject of many controversies. The QT interval represents the time interval of both ventricular depolarization and repolarization. Not only abnormalities of ion channels, but also changes in the myocardial microarchitecture and other factors and disorders frequently seen in cancer patients may participate in its prolongation and potential risk of ventricular arrhythmias. The aim of this review was to summarize current knowledge about QT prolongation in cancer patients with the special focus on targeted therapy.

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Key words: QT prolongation, targeted therapy, torsade de pointes, cancer patients
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Dodany 2017-09-05
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Wielkość 199.11 KB
Dodany przez Marcin Kuźma
Pobrany 299


OncoReview 2016; 3(23): 100-102

Autorzy: Saro Armenian, Daniel Lenihan

Streszczenie: 

Abstract: The initial presentation in this session was a comprehensive outline of Late onset cardiotoxicity: incidence, risk and individual risk prediction by Dr Gregory Armstrong from St. Jude’s Children’s Hospital in Memphis, TN.

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Dodany 2017-09-05
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Wielkość 174.54 KB
Dodany przez Marcin Kuźma
Pobrany 275


OncoReview 2016; 3(23): 97-99

Autorzy: Daniel Lenihan, Benjamin D. Humphreys

Streszczenie: 

Abstract: An outstanding opening lecture by Thomas Wang, MD, Chief of the Division of Cardiovascular Medicine at Vanderbilt UniversityMedical Center, outlined the field of biomarkers in cardio-oncology.

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Dodany 2017-09-05
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Wielkość 110 KB
Dodany przez Marcin Kuźma
Pobrany 261


OncoReview 2016; 2(22): 62-65

Autorzy: Agnieszka Buraczewska, Joanna Kardas

Streszczenie: 

Abstract: Papillary renal cell carcinoma is the second most common histological type of renal cell carcinoma with distinct cytogenetics, histology and prognosis. It exhibits significantly poorer response to molecular targeted therapies, which are about the progress in clear-cell carcinoma. We present an overview of the treatment trials and report a casuistic case of metastatic disease controlled for several years with pazopanib.

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Key words: papillary renal cell carcinoma, molecular targeted therapies
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Dodany 2017-09-05
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Wielkość 105.62 KB
Dodany przez Marcin Kuźma
Pobrany 297


OncoReview 2016; 2(22): 49-56

Autorzy: Rafał Mańczak, Michał Wilk, Anna Walaszkowska-Czyż, Michał Florczyk, Sebastian Szmit

Streszczenie: 

Abstract: We present a case of 68-year-old female with severe symptomatic aortic stenosis and locally advanced breast cancer disqualified from mastectomy due to heart failure and from aortic valve replacement due to malignant neoplasm. The patient received neoadjuvant chemotherapy without anthracyclines. The aortic valve replacement was performed and then mastectomy and lymphadenectomy were made without hemodynamic complications. Adjuvant hormonotherapy was started. During 42 months of follow-up the patient remained free of recurrent cancer disease as well as no progression of heart failure was observed.

Słowa kluczowe:

Key words: aortic stenosis, breast cancer, anthracyclines, aortic valve replacement, echocardiography
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Dodany 2017-09-05
DOI:
Wielkość 564.44 KB
Dodany przez Marcin Kuźma
Pobrany 294