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Kategoria: OncoReview
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OncoReview 2015; 2(18): 76-80

Autorzy: Anna Ciszewska, Łukasz Głogowski, Andrzej Witkoś, Zofia Rusinowska, Ewa Nowakowska-Zajdel

Streszczenie: 

Abstract: Paraneoplastic neurological syndromes (PNS) are a group of rarely observed disorders, accompanying about 1% of cancer diseases.Paraneoplastic neurological syndromes (PNS) are a group of rarely observed disorders, accompanying about 1% of cancer diseases.They have a typically aggressive course, leading to profound and essentially irreversible disability. The pathogenic cause behind PNS is damage of the nervous system structures as a consequence of the body’s immunological reaction induced by cancer. Onconeuralantibodies generated as part of the reaction target the tumour tissues, but also the regular nervous tissue recognized as antigens.Presence of onconeural antibodies reveals a 50–60% sensitivity and 100% specificity in diagnosing PNS. Imaging and laboratory tests have a limited impact on diagnosis. What is crucial is the analysis of clinical systems following Graus’s criteria (elaboratedin 2004). In the case presented here, the patient underwent treatment in many neurological departments due to the symptoms of progressive damage of the nervous system. She was eventually diagnosed with the stiff person syndrome related to breast cancer.In spite of the treatment, including an efficacious oncological therapy, the severe neurological deficit resulted in serious motordisability 

Słowa kluczowe:

Key words: paraneoplastic neurological syndromes, breast cancer, stiff person syndrome
Informacje o publikacji
Dodany 2017-09-05
DOI:
Wielkość 154.7 KB
Dodany przez Marcin Kuźma
Pobrany 299


OncoReview 2015; 2(18): 53-56

Autorzy: Anna Raciborska, Katarzyna Bilska, Jolanta Antoniewicz, Magdalena Rychłowska-Pruszyńska, Carlos Rodriguez-Galindo, Anna Fijałkowska

Streszczenie: 

Abstract: We describe a case of a 2-year-old boy with neuroblastoma and high catecholamine levels which developed a severe hypertensiveWe describe a case of a 2-year-old boy with neuroblastoma and high catecholamine levels which developed a severe hypertensivecrisis. An oral propranolol and oral angiotensin-converting enzyme inhibitor were used with a mild short transientbenefit. However, an intravenous labetalol and oral doxazosin used for over 3 weeks resulted in successful blood pressure control.This report highlights the prolonged use of α and β-adrenergic antagonist therapy in children with neuroblastoma withrefractory catecholamine-induced hypertension.

Słowa kluczowe:

Key words: neuroblastoma, hypertensive crisis treatment, labetalol, doxazosin, children
Informacje o publikacji
Dodany 2017-09-05
DOI:
Wielkość 176.56 KB
Dodany przez Marcin Kuźma
Pobrany 320


OncoReview 2015; 1(17): 27-32

Autorzy: Marina F. Ballyuzek, Boris P. Stepanov, Anna K. Ionova, Maria V. Mashkova

Streszczenie: 

Abstract: Types of oncological rehabilitation and its objectives are described. It includes information on many manifestations of oncological diseases that an internist has to deal with, which are conditioned not only by the oncological process itself, but by the cancer treatment conducted, as well as the attitude of doctors and patients to cancer pathology. The specific characteristics of the “cancer disease” are described, as well as a combination of somatic disorders which depends on the ongoing or arrested tumor development. It is necessary for doctors to observe the cancer patients before, during and after treatment for complication of cancer or treatment over the life span.

Słowa kluczowe:

Key words: cancer patients’ rehabilitation, oncological rehabilitation in therapists’ practice, paraneoplastic syndrome, cancer disease, somatic disorders accompanying oncological pathology
Informacje o publikacji
Dodany 2017-09-05
DOI:
Wielkość 156.45 KB
Dodany przez Marcin Kuźma
Pobrany 274


OncoReview 2015; 1(17): 5-10

Autorzy: Asma Mursleen, Eric E. Harrison

Streszczenie: 

Abstract: Doxorubicin chemotherapeutic agent is widely utilized for many types of cancers since the late 1960s. Cardiomyopathy is a well-known side effect of doxorubicin often limiting its use. In many cases doxorubicin cardiomyopathy can lead to end stage cardiac failure requiring heart transplantation. The quality of life of heart transplant patients is exceptional with most patients being able to continue normal activities following recovery. There has been significant advancement in cardiac transplantation since it was first attempted in 1967 in Cape Town, South Africa. Drugs such as cyclosporine played an important role in preventing graft failure and prolonging patient survival. Cardiac transplant can extend a patients’ life by over a decade. The patient in this case, Mr. Glen Frank Spurling, has survived 30 years following his cardiac transplant surgery. In this article an overview of doxorubicin cardiotoxicity, cardiac transplantation, and an interview with Mr. Glen Frank Spurling is presented.

Słowa kluczowe:

Key words: heart transplantation, doxorubicin cardiomyopathy, heart transplant survivor
Informacje o publikacji
Dodany 2017-09-05
DOI:
Wielkość 272.4 KB
Dodany przez Marcin Kuźma
Pobrany 261